Biosource Consulting

Strategic Resources for Entrepreneurs

Tag Archive: Biotech Industry

  1. 1 of 7 Common Entrepreneur Mistakes: Unclear Goals

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    ThiAlice and Cat3s is the first in a series of seven common entrepreneurial mistakes, and how to fix them.  Although the context will be biotech entrepreneurs, these principles apply to all entrepreneurs.

    One of the most critical mistakes entrepreneurs make, is not clearly defining their goals at the outset, in terms of their business model and product development goals.  Investors instinctively know whether an entrepreneur really understands where they are going, or if they are just on a “fishing expedition,” hoping to figure out things—after they get their money. Your business model and product development goal impacts many things.

    For example:

    • Is your business goal to incrementally advance your technology and increase its value while at staying employed at your academic institution, then to consult for the company that licenses, develops and commercializes your future product?
    • Is your business goal to advance your technology all the way through to product commercialization?
    • Is your business goal to develop a prototype or reach preclinical stage, then license the project to a Med Device, Pharmaceutical Company or Diagnostic Company?
    • Is your business goal to develop an In-Vitro Diagnostic test kit, or are you wanting to reach to the market faster as a Laboratory Developed Test (LDT) as a clinical service model?

    Recognize that the choice of a business goal effects the optimal enterprise structure, the amount of capital you need, and the time required to reach an investor exit. Each of which have differing amounts of risk and differing valuations.

    Here is an analogy why it is critical to define your goal at the outset.  Suppose ten people living in Oklahoma City have a common goal of arriving at New York City by automobile. Each one can choose from dozens of different routes to reach this destination. Some choices will allow an individual to arrive sooner, other choices will cause an individual to arrive later, but all ten individuals will eventually reach the same destination—as long as they constantly head northeast.  The moment someone heads south, west, or northwest…they will not arrive at their goal!

    This may seem remedial, but it is an important analogy. If your business goal is defined at the outset, you and your team can use their creative ability to overcome obstacles to arrive at your desired destination. However, if your business goal is not clearly defined, often weary entrepreneurs will take the path of least resistance, only to later discover that their past decisions are directing them away from their desired goal.

    Recognize the Difference between the Goal and a Method

    Starting and building a biotech company or entrepreneurial organization is not prescriptive!  Although there are defined concepts and principals to follow, many paths can lead to success. For instance, when raising capital, one entrepreneur will be successful by building their company with non-dilutive capital in the form of grants, donations and crowdfunding. However, if this funding “method” becomes the “goal” for another entrepreneur who cannot raise non-dilutive capital, they waste precious time trying to achieve a “goal” that was simply one of many methods for raising capital. Recognize that there are many methods to reach the same goal.

    How to Avoid this Mistake?

    Every entrepreneur begins with a product idea from technology they developed or plan to license. During this time, before the company is incorporated or launched, there usually is no overhead cost structures or payroll to maintain. It is during this time that a variety of goals should be examined, tested and defined—prior to starting the organization.  This is a time when literally no one is looking at your organization and you can make as many mistakes as you want—and no one even notices. During this time, practice sharing your vision and goal with other seasoned entrepreneurs, then listen to their feedback. Share your goal with others in the industry and see if they get excited about your vision. If you already launched your company and you are struggling, re-examine your business model and product development goals to see if they are truly aligned with an acute market need. Always be sure to reduce your product concept and business goals into understandable terminology so that even your grandmother can understand. If you successfully do this, and people get excited about your goal, you may be on to something.

    Can your Goal Change?

    Absolutely! In fact, a good number of successful businesses and products are the result of a strategic business change that occurred because of an insurmountable roadblock in the original product idea or market. However, you first need to have a goal defined before you can change it! I’ll share more about this principle in Mistake #6 “Not Knowing When or How to Pivot or Reinvent Your Business Model or Product—missing critical external queues and failing to take advantage of “serendipity.”


    For entrepreneurial success, you must clearly define your business model and product development goals. Well-defined goals provide a destination that team members can get behind and help to overcome obstacles and roadblocks that are encountered along the way. Entrepreneurs must clearly identify their goals at the outset because those who join your team are motivated by your vision, and your goal is the description of your ultimate destination. If you fail to define your goal, like the reply from the Cheshire cat to Alice when she asked him “which road do I take?” he said, “If you don’t know where you are going, any road will take you there!” Be an entrepreneur with clearly defined goals, so others can creatively help you reach your destination.

    © 2015 Craig Shimasaki

  2. 7 Common Mistakes of Entrepreneurs and How to Fix Them

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    oopsMost entrepreneurs start out with great optimism because they perceive in their minds a visionary product or service that could revolutionize some facet of work, life, industry or medicine. First time entrepreneurs embark on this journey with lots of energy and motivation that propels them to step out into this high-risk endeavor. However, most entrepreneurs are not aware of the “Unknown-Unknowns.” These are the things they don’t know…that they don’t know.  Unknown-Unknowns are harder to fix when you don’t recognize there are critical entrepreneurial problems looming ahead.

    I am a firm believer of the quote by Eleanor Roosevelt (or Groucho Marx–whomever really quoted) “Learn from the mistakes of others because you will never live long enough to make them all yourself.”  I believe the title “Seasoned Entrepreneur” is really a subtle reference to individuals who have accumulated the most battle scars during their entrepreneurial journey–and survived to tell about it! I would like to share some of these lessons because there are many pitfalls for entrepreneurs, but most of them are avoidable with careful planning and advanced knowledge. I have narrowed these mistakes down to seven of the most common categories.

    1. Unclear Goals: Not knowing where you are going and not recognizing the difference between a Method and a Goal.
    2. Misaligned Technology with a True Market Need: You find yourself possessing a technology solution that is in search of a problem to solve.
    3. Poorly Planned Corporate Entity and Agreements: These foundational legal problems impact your future ability to raise capital and grow.
    4. Failing to Fully Leverage your “Human Capital”: There are unrecognized and untapped resources available that you need, but you are not utilizing.
    5. Poor Capital Management and Fundraising Strategy: Your capital raises are not timed to occur after reaching a value-enhancing milestone, thus impacting investor interest and valuation.
    6. Not Knowing When or How to Pivot or Reinvent Your Business Model or Product: Missing critical external queues and failing to take advantage of “serendipity.”
    7. Short-term Perseverance and Limited Vision: Misaligned internal motivation which ultimately leads to a self-limiting enterprise.


    I’ll post more about each of these topics in the upcoming weeks.

    © 2015 Craig Shimasaki

  3. How to Develop a PowerPoint Pitch Deck for Biotech Investor Presentations

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    or…“How to persuade individuals who have money—to share some with you”

    Continuous Flow of Capital is Vital

    Cash Flow FaucetFew issues are more important to start-up and development-stage biotechnology companies than maintaining a continuous flow of capital—if you hope to advance the development of your product and market in an uninterrupted manner. The amount of capital you raise, and your company’s development stage, will dictate the type of investors who are attracted to your enterprise.

    A critical tool for all biotech entrepreneurs is an Investor Slide Deck or “Pitch” Deck. This is typically a collection of PowerPoint slides used for communicating your deal to different groups of investors. Since capital is the lifeblood of your company, having a well-thought-out Pitch Deck is a vital asset for all biotech entrepreneurs. To address this I have put together some basic information about what a biotech investor pitch deck should contain when presenting for the first time to a group of potential investors.

    Creating a biotechnology product is vastly different from other industry products, therefore, the topics that biotech investors want to hear about also differ. Unlike IT products and other technology products, biotech products have longer development timeframes, more exorbitant development costs, much more stringent regulatory requirements, and a unique need for diversely-skilled individuals. Therefore, one cannot use a generalized entrepreneurial pitch deck when pitching to biotechnology investors, however, there are some key topics that remain universal. Gratefully, biotech products are also unique in their significance to society and in the type of returns possible for investors.

    The Pitch DeckPowerpoint Presenter2

    The outline below and the accompanying PowerPoint Investor Pitch Deck example are provided to help those who need guidance on what topics and information are important for a biotech investor presentation. Realize that this is not a template per se in which to simply fill in the blanks, but an ordered list of topics that are significant to most all biotechnology investors.

    In reality, you should always tailor your slide deck to the particular audience and their interests; whereas the number of slides and the depth of information surrounding any particular topic are dictated by the time allocated for that meeting. However, in an attempt to provide a basic and universal outline for preparing a biotech investor pitch deck, this will give you a starting point.

    16 Topics to Cover: Basics of an Investor Pitch Deck for Biotech Entrepreneurs

    This is my preferred slide order when “telling the story”. I find that this order makes sense to the listener and is easy to follow as it builds upon preceding information. There are different opinions on which topics to cover and their sequence order. For example, some suggest that the Leadership Team be presented at the beginning rather than toward the end of a presentation. My opinion is that unless you have a stellar and complete Dream Team, then first sell the audience on the opportunity and the novelty of the idea. Whatever your topic order, make sure you tell a story that unfolds logically and be sure that the information is relevant to the investor audience you are pitching.

    Above all, do not present a haphaTell Your Storyzard mosaic of subjects in an illogical sequence that confuses your listening audience. For instance, don’t start talking about your technology and product benefits before you first explain the significance of the “problem” or “pain” as it relates to your target market. Although some listening individuals may already be familiar with the problem you are addressing, not everyone will. And certainly everyone will not be aware of the nuances of this problem, yet these issues could be key to appreciating your product’s value proposition.

    It is always important to remember that the majority of biotech investors are driven by “data”. Therefore present reproducible data on the technology, share data supporting your market need, describe data supporting insurance reimbursement for your product, include data when available on all other topics discussed, and don’t forget to cite credible sources.

    Slide Deck Topic Order

    1.  Company, Purpose, Mission and History (relevant information only)

    *  Describe the focus and purpose of the company
    *  Tell where the technology originated, if significant
    *  Describe the current stage of development (Start-up company or Phase 1 clinical trials)
    *  Tell why you are there, and share the “Ask”— how much money are you raising? (Example: Seeking $1.5MM in Convertible Notes)

    2.  Problem or “Pain” – Explained in a way that lets the investors feel or know the pain of the problem

    *  Describe the issues with the current status quo (problem with diagnosis, treatment, manufacture, etc)
    *  Help the investors understand the problems those suffering with this condition face, or the issues someone has to deal with in this situation (describe in terms of limitations, costs, inconveniences, ineffectiveness, etc)
    *  Discuss why is there a problem

    3.  Technology and Product Solution

    *  Describe how your product or technology solves this big problem
    *  Show data, results, prototype testing and evidence that the technology or product works or will work, or has a very high likelihood of success
    *  Demonstrate to the audience that your data supports the likelihood of product success, or show its significance in leading to product success
    *  Describe the mechanism-of-action (non-confidential version), how it works (if you know). You don’t need to reveal trade secrets or confidential information here

    4.  Competition and Substitutes Currently Used

    *  Summarize the competitors and list any products or substitutes
    *  Describe products that may be coming out in the future and from whom
    *  Discuss the willingness of users to change from the current status quo
    *  Elaborate on your product’s points-of-differentiation and discuss the significance of your advantages
    *  Address why no one fixed this problem yet

    5.  Market Opportunity and Strategy

    *  Estimate the market size and be prepared to describe how it is calculated or provide sources (use credible sources only)
    *  Tell who is your Target Market and who is your secondary market – describe how you will reach your customers
    *  The amount of detail here depends on the biotech sector and the condition/disease/industry you are targeting (some market sizes are well-understood)
    *  Explain why the timing is right for your product

    6. Business or Revenue Model

    *  Show how you are going to make money
    *  Describe the partnerships that are needed in order to be successful
    *  Discuss any distribution channels needed and the status of these relationships

    7.  Reimbursement Strategy

    *  Show proof of reimbursement that is related to your product or provide supportive comparisons
    *  Describe your pricing model if applicable
    *  Show any pharmacoeconomic models or data to support the type and amount of reimbursement for your product

    8.  Product Development and Regulatory Pathway

    *  Describe your current product development status and the progress made to date
    *  List your next product development milestones and the estimated timeframe to reach these
    *  Describe your regulatory route, timing, and issues you face and how they will be mitigated
    *  Briefly discuss any potential follow-on products supported by this technology

    9.  Intellectual Property and Secret Sauce

    *  Share what patents are filed or issued and indicate whether or not you have trade secrets
    *  If available, discuss findings from your Freedom to Operate opinion
    *  Share your technology license terms, royalties and milestone fees (if any)

    10.  The Leadership Team

    *  Discuss your senior management team and their relevant experience and their past successes
    *  Describe the background of your Advisors/Consultants/Board Members if formed
    *  Candidly discuss whether or not your team is complete and who else is needed and with what backgrounds
    *  Describe any key partnerships formed or those in progress

    11.  Estimated Exit, Potential Acquirers and Timeframe

    *  Share your presumed exit – VCs will know this but it is helpful if they know you know, and most Angel investors want to hear this
    *  Briefly share data on exit valuation or exit revenue multiples for your sector
    *  It is not wise at this stage to share your opinion on a “pre-money valuation” for your company as this will be based in part upon investor interest, and is negotiable. Preconceived opinions at this point may limit investor interest.

    12.  Financials

    *  Ideally, provide a five-year Pro Forma projection of future revenue (if relevant – generally not needed for therapeutics), share your assumptions and be sure to build with “bottom-up” rather than “top-down” calculations
    *  Describe the total funds raised to date, and what these funds were used to accomplish, describe grant funding if awarded
    *  Share your estimates for future funding needs to reach commercialization, and estimate the number of additional financing rounds
    *  Show your generalized Use-of-Proceeds for this fund raise

    13.  Risks and How They Will be Mitigated

    *  This slide is not always necessary, but risk mitigation issues must be addressed during the presentation or during the Q&A
    *  Alternatively, risk mitigation information can be incorporated within each topic as it is addressed or they can be placed in the summary slide depending on the investor audience and time allotted
    *  Investors know that you cannot manage a risk that you have not identified

    14.  Summary

    *  Recap any key highlights relevant to this audience and include any points you want them to remember

    15.  Thank You/Question & Answer Time

    *  Thank the audience (this does not necessarily have to be a slide, but be sure to acknowledge your appreciation for this opportunity and for any particular efforts made for you to speak to this audience
    *  Q&A typically starts here. However, be aware that some investor groups do not wait for the last slide to ask all their questions
    *  A good sign of potential interest is when investors ask many questions and become very engaged after your presentation
    *  Investors who have made up their mind not to invest, typically do not have many questions

    16.  Support Slides

    *  These slides are kept in reserve and are selected and shown based upon questions asked by investors
    *  The number and content of these slides are your choosing. Be prepared with additional and more detailed information on any topics you anticipate this investor audience may ask

    How Many Slides do I Need?

    Although the topics I have described are numbered, they do not represent the total number of slides needed, sometimes it can be more or less. The exact number of slides you use will depend on the following:

    *  The time allotted for the investor presentation (leaving time for Q&A)
    *  The backgrounds of the investor audience
    *  Their key issues with the product, technology, market or the business model
    *  Which issues are relevant to your technology and product success

    Just be sure to cover or touch on each listed topic to a lessor or greater degree, as all are significant to an investor. Some of these topics can be combined, depending on your sector and product technology. However, the depth of you discussion on any topic will depend on the issues surrounding that topic. For instance, if every predecessor product in your sector has previously failed somewhere in the regulatory process, you will need to spend more time explaining why yours is different and has a higher likelihood of success.

    A good rule of thumb for determining the number of slides in your pitch deck, is to presume that you need 1-2 minutes per slide, minus the time set aside for Q&A. For instance, if you are allocated 30 minutes for an investor presentation, plan on about 15-20 minutes for your slide presentation which would be no more than 15 slides, then allocate 10-15 minutes for Q&A afterwards. You can always elaborate in more detail if fewer questions are asked. However, you do not want to be cut off before finishing your presentation because you ran out of time.

    In this blog I principally address the “content” and the subject matter of a good biotech investor presentation. I have not dealt with the issues related to slide formatting and presentation etiquette, since there is abundant publicly available information about these subjects. Just be sure to incorporate visual aids when discussing complex technology and make use of graphs and figures when explaining concepts rather than simply using only text.

    For those wanting more information about presentations and creating a business plan, read Chapter 22 titled “Your Business Plan and Presentation: Articulating Your Journey to Commercialization” in my latest book “Biotechnology Entrepreneurship: Starting, Managing and Leading Biotech Companies.”

    What Investors are Looking For That is Not in Your Slides

    Investor ExaminerIt is important to understand that not everything an investor is looking for is contained within your slides. I have listed a few of the characteristics investors look for in a biotechnology entrepreneur during this face-to-face meeting. These “unspoken” characteristics are observed and identified throughout your presentation and more importantly, during the Q&A session after your presentation. These are not necessarily qualities you can “practice” for a presentation, although all individuals can improve on them if they desire. Rather, these are inherent characteristics within an individual. When presenting, you want to be yourself and be comfortable, rather than “perform” in a manner that you think an investor wants to see and hear. I would advise that you assess these character qualities within yourself before you begin raising capital. A good way to do that is to ask individuals close to you if they can observe any of these characteristics within you.

    Important Entrepreneurial Characteristics That Are Not Contained in Your Slides

    *  Passion for your work
    *  Enthusiasm
    *  Intricate and working knowledge of your business, product and market
    *  Good strategic thinking
    *  Ability to inspire others and ability to execute
    *  Willingness to receive advice, listen and learn
    *  Leadership characteristics
    *  Culture fit

    The Takeaway Tidbit

    ToolsMaintaining a continuous and steady stream of capital is critical for all development-stage biotechnology companies wanting to become successful. Since capital comes from investors, the biotech entrepreneur must be able to skillfully convey relevant information supporting an investment decision in their company. In order to do this one must know the pertinent issues for any investor. It is an unfortunate situation when a biotech entrepreneur has a great product opportunity, yet they derail the investment process because they do not understand how or what to communicate to sophisticated investors.

    Biotech entrepreneurs should start by developing a well-thought-out pitch deck addressing these basic topics. You can later modify the depth and detail of information according to any investor interest or the issues relevant to their concern about your organization and product technology or market. By possessing a solid pitch deck covering each of these relevant topics, a biotech entrepreneur will have a tool to communicate to investors the relevant information necessary for making investment decisions. By first creating a thorough and well-developed Investor pitch deck, you can later selectively modify or consolidate this information into any presentation length and adapt it for other investor audiences, and thereby have at your hand, a ready tool to raise capital for your company.

    Copyright 2015 © BioSource Consulting. All Rights Reserved


  4. The Benefit of Biotechnology Experience

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    Boyer-Swanson-300x212When venture capitalist Robert Swanson, and biochemist Dr. Herb Boyer each put in $500 to start Genentech in 1976, it could hardly be said that they knew what they were getting into, or how they were going to make their company successful. Few biotechnology companies existed before, and there were no successful “biotechnology business models” to follow.  However, these founders had a clear vision and a burning passion to use this newly discovered recombinant DNA technology to create disease treatments that were previously deemed “impossible”. This tool became known as “Genetic Engineering Technology”, hence the name Gen-en-tech.

    Since its founding, Genentech scientists have developed some of the world’s first recombinant human therapeutics such as Recombinant Human Insulin, Recombinant Human Growth Hormone, Recombinant Human Tissue Plasminogen Activator (tPA) and many others. Then in March 2009, Roche and Genentech agreed to a complete buyout of the company for $46.8 billion dollars, for 56% of Genentech’s remaining outstanding shares that Roche did not already own.  Not a bad return for a $500 investment in 1976.

    Since its founding, Genentech scientists have developed some of the world’s first recombinant human therapeutics such as Recombinant Human Insulin, Recombinant Human Growth Hormone, Recombinant Human Tissue Plasminogen Activator (tPA) and many others. Then in March 2009, Roche and Genentech agreed to a complete buyout of the company for $46.8 billion dollars, for 56% of Genentech’s remaining outstanding shares that Roche did not already own.  Not a bad return for a $500 investment in 1976!

    There was no doubt that between 1976 and 2009, Genentech experienced numerous, and sometimes disastrous, trials and errors in their product development, regulatory approvals, marketing and corporate development.  Since no best practices were available to follow in this fledgling industry, and there were few experiences to draw from, and no serial biotechnology entrepreneurs to listen to, the company founders forged ahead by sheer instinct, and created their own best practices as their company grew.

    Today, the biotechnology industry is over 35 years old with thousands of biotechnology companies worldwide, and many of these companies have been started by serial biotechnology entrepreneurs.  Sound business models are now available and there is plenty of experience to draw from for those contemplating starting and growing a biotechnology company. However, the challenge is often finding these resources and getting serial entrepreneurs to share their candid insights and experiences. All biotech entrepreneurs can save time and avoid costly mistakes if they avail themselves to as much practical experience as possible.  This old saying does have an element of truth, “learn from the mistakes of others because you will never live long enough to make them all yourself!”

    Beginning May 15 through June 12, 2012, a 5-week, webinar series titled “The Business of Bioscience: What Goes Into Making a Biotechnology Product” will be presented by Dr. Craig Shimasaki, and sponsored by the National Council of Entrepreneurial Tech Transfer (NCET2).  This 5-series web-based presentation will cover the author’s 28 years of experience as a serial entrepreneur of three biotechnology companies.  He will share insights that will help those wanting to take their product idea through to commercial development, and the author will describe how to navigate the challenges of building a successful biotechnology company.

    The series covers five, 90-minute class sessions walking participants through the steps biotechnology entrepreneurs take when developling a product and building a company.  At the end of each session the participants can submit questions to the presenter.  This webinar covers insights from the author’s book “The Business of Bioscience: What Goes Into Making a Biotechnology Product” which will serve as an in-depth reference and resource.

    To register for this series click on the Research Commercialization Online Courses and Webinars

    To purchase a copy of the reference book click on this link “The Business of Bioscience: What Goes Into Making a Biotechnology Product”

    Copyright 2015 © BioSource Consulting. All Rights Reserved

  5. Can I Start a Company and Still Remain an Academic Professor or Physician?

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    You may be a Professor or Practicing Physician at a University or Research Institution and ask the question “How can I start a biotech company if I don’t really want to run it?”

    Don’t worry! You don’t have to be CEO in order to start your own biotech company.  In fact, it may not be the best advice to become CEO if you have no previous business experience.  An academic scientist CEO without prior business experience can sometimes be an impediment to raising money because investors bet on experienced people – not just in technologies alone.  Although there are examples of scientists and physicians leading successful biotech companies, unfortunately, stereotyping of scientists and physicians does occur. As a general rule, the more practical business experience you possess, the more confidence investors will have in your ability to successfully lead a company.

    As a professor or practicing physician, you can assist in starting and forming your new company, help develop the technology and participate in its value creation without having to leave your academic or clinical position.  But even if you are interested in leaving your position now or in the future, you still don’t have to run the entire organization unless that is your desire.  There are several ways to participate in the entrepreneurial process without shouldering the responsibility for the entire organization.  However, just because you are not leading the organization, it does not mean you cannot participate in shaping its future. There are several alternative roles you can assume that still provide valuable experience for participating in the entrepreneurial process and better equipping you for a subsequent entrepreneurial opportunity.

    Alternatives to Taking the Leadership Role

    It is important to first decide your time commitment to the new entity.  Are you interested in full-time participation or only part-time?  Do you only want to participate in this new venture as a consultant on an “as needed basis”?  Would you like to start on an “as needed basis” yet have the opportunity to later participate full-time?  If you first identify your time commitment interest, it will help in selecting your entrepreneurial options.  If you are contemplating starting a biotechnology but are not interested in leading the organization, here are some ways you can participate:

    1. Take a position as Chief Scientific Officer, Medical Officer or Vice President of R&D.  Participate by leading the technology or clinical development but have someone else shoulder the business and financing responsibilities of the organization.

    2. Participate as a Scientific or Medical Advisory Board Member and assist in the overall direction and in solving problems during the technology development

    3. Participate as Scientific or Clinical Consultant and assist on an “as needed basis”

    In the beginning, you will be heavily involved in establishing the company, and you must be willing to commit a large portion of your time during this phase.  Afterward, you can then return to academic research or medical practice, while contributing an alternate role as described above.  As a founder of the company you will most likely be involved in securing seed funding for your new venture, which may come in the form of grants and/or seed capital funding from angel investors.  During this time you must identify and recruit an experienced CEO or a former entrepreneur who can give you guidance on how to move the technology forward. Initially, you must be the sole driving force behind the company, understanding that your work will have benefit later when you reap the rewards of your efforts.  By participating in these alternate roles it will better prepare you for subsequent start-up options where you may want to assume the leadership role.

    The Takeaway Tidbit

    Professors and physicians with minimal business experience may want to consider supportive roles in their new venture rather than taking responsibility for the entire organization.  In this way, you can learn by participating as a member of the team, rather than being solely responsible for the outcome of the company.  By doing this, you will gain valuable experience and can be applied to your next opportunity.  You can then lead with more confidence because you will then understand the start-up process and the issues you may face.  It is essential to work with other experienced people because a good team is vital to business success.  For those who are interested, more information about these alternative roles can be found in the chapter titled “What Makes a Biotech Entrepreneur”, in the book “The Business of Bioscience: What Goes Into Making a Biotechnology Product”.

    Copyright 2015 © BioSource Consulting. All Rights Reserved

  6. How Much is Your Company REALLY Worth?

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    Determining Valuation for Early and Latter Development-Stage Biotechnology Companies –

    All biotech entrepreneurs at some point must address the question “how much is your company worth?” The answer determines the slice of equity for yourself, employees, and current and future shareholders.  As a result, most BioEntrepreneurs tend to overvalue their company at the start-up and early development stages.  However, overvaluing your company is counterproductive and detrimental to attracting institutional and venture capital during these critical stages.  Although there are standard valuation methods for determining the value of growing companies with product revenue, how do start-up and preclinical stage biotechnology companies without product revenue value their organization?


  7. How Does an Entrepreneur Find Venture Capital For Their Business?

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    The lifeblood of a young biotech company is cash.

    Without capital, the greatest of ideas get nowhere.  The biotech entrepreneur must successfully identify and access consistent sources of capital over the life of their organization in order to transform their ideas in to products.  During early development stages the entrepreneur should make use of Angel capital and Small Business Innovative Research (SBIR) and other federal (NIH) and state grants.  But at some point this budding company will need to secure venture capital or what is known as Institutional Funds.  How does one go about doing this?

    Kleiner, Perkins, Caufield &  Byers (KPCB) is one of the stalwart biotech venture capital groups and one of the early backers of Genentech in 1977.  Since then, the firm and its Partners have backed entrepreneurs in over 100 life science companies working in every area of medicine, including cardiology, cancer, neurology, immune system diseases, ophthalmology, and molecular diagnostics.

    Stanford University’s Entrepreneurship Corner interviewed Brook Byers, an early partner in the firm discusses the best way an entrepreneur should find and reach venture capitalists.

    In this second video clip he shares his thoughts on selecting and working with venture capital firms. (more…)

  8. The Biotech Industry is Finally Profitable! So What Does That Mean?

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    up down chart A recent report from Ernst and Young acclaimed that the biotechnology industry finally reached profitability for the first time in history with a net income of $3.9 billion in 2009 (Beyond Borders: Global Biotechnology Report 2010). This is a significant milestone and welcome news!  However, to put this in perspective, Wal-Mart, General Electric and AT&T individually had net incomes of about 3-4 times the total biotech industry ($13.4 billion, $17.4 billion and $12.9 billion respectively).

    The biotech industry is only about 35 years young.  However, in spite of reaching profitability, some still say the biotechnology business model is broken.  (more…)